Epidemiologic study of pediatric uveitis and its ophthalmic complications using the Korean National Health Insurance Claim Database.

Purpose: To investigate the incidence and ophthalmic complications of pediatric uveitis using the Korean National Health Insurance (NHI) Service database.

Design: Nationwide population-based longitudinal cohort study.

Methods: This study used the NHI database from 2005 to 2021 and included individuals <18 years of age diagnosed with uveitis on at least three separate visits between 2010-2014, with a five-year wash-out period and a seven-year follow-up period.

Stay Put or Move Out? A Review of Acute Respiratory Illness Transfers Out of a Peripheral Centre and Their Characteristics: A Retrospective Cohort Study.

Aim: To describe the characteristics of children transferred out of a peripheral centre for the management of acute respiratory illness and explore opportunities for decentralising paediatric high dependency care.

Methods: A single-centre, retrospective cohort study, including children transferred out of a peripheral centre with diagnoses of asthma, bronchiolitis, pneumonia and pleural effusion. Patient characteristics and management were recorded from the medical records.

Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.

Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorigenesis in a range of cancer types, but its role in PC has yet to be explored.

Stereotactic body radiotherapy for oligoprogressive disease in androgen suppressed prostate cancer: Primary endpoint analysis of the TRAP trial.

Purpose: Optimal management of oligoprogressive prostate cancer whilst on androgen receptor pathway inhibitors (ARPi) is not known. The **** trial tests the role of stereotactic body radiotherapy (SBRT) in this setting. The objective of this Phase II prospective, non-randomised, single arm trial was to determine if local control of oligoprogressive disease with SBRT can delay further progression by more than four months, postponing time to next therapy.