Publications by authors named "A Khoynezhad"

Aortic dissection is the most common thoracic aortic emergency and is associated with significant morbidity and mortality. Initial complications are dependent on reduction of sheer stress against the aortic wall to protect against rupture and minimize progression of the aortic wall injury. In patients with dissection starting at or distal to the left subclavian artery (Stanford type B), initial management includes strict blood pressure and heart rate control with monitoring for any complications such as malperfusion, rupture, or hemodynamic instability.

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Article Synopsis
  • Atrial fibrillation (AF) is a common complication after cardiac surgery, but the causes of postoperative AF (POAF) are not well understood, prompting this study to explore gene networks related to POAF using bioinformatics.
  • Researchers analyzed data from the Gene Expression Omnibus (GEO) database, identifying 2 key gene modules and 44 significant genes associated with POAF through weighted gene co-expression network analysis (WGCNA).
  • The study also unveiled a circRNA-miRNA-mRNA regulatory network, highlighting 2 novel circRNAs and 2 miRNAs that may play crucial roles in the biological processes linked to POAF, providing a deeper understanding of its mechanisms.
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Background: Despite significant technological advancements in endovascular aortic repair, the aortic arch remains a challenge due to anatomic complexity including arch angulation and morphology as well as the location of brachiocephalic vessels in relation to landing zones. Total endovascular solutions are in development and being studied, in the meantime, hybrid thoracic endovascular aortic repair (TEVAR) is a viable alternative to traditional open total arch replacement.

Methods: A retrospective case series was performed reviewing outcomes of 71 patients who underwent hybrid TEVAR in the aortic arch over the past 12 years at our facility.

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Background: Shone's complex is a rare congenital heart disease consisting of a variety of left ventricular inflow and outflow tract lesions. Patients typically present in childhood requiring early surgical intervention; however, with improved surgical techniques, these patients are surviving later into adulthood. This increased survival comes with a new set of medical complications that providers need to be aware of.

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