Publications by authors named "A Khojasteh"
Tissue Engineering 3D-Printed Scaffold Using Allograft/Alginate/Gelatin Hydrogels Coated With Platelet-Rich Fibrin or Adipose Stromal Vascular Fraction Induces Osteogenesis In Vitro.
J Cell Physiol
December 2024
Incorporating autologous patient-derived products has become imperative to enhance the continually improving outcomes in bone tissue engineering. With this objective in mind, this study aimed to evaluate the osteogenic potential of 3D-printed allograft-alginate-gelatin scaffolds coated with stromal vascular fraction (SVF) and platelet-rich fibrin (PRF). The primary goal was to develop a tissue-engineered construct capable of facilitating efficient bone regeneration through the utilization of biomaterials with advantageous properties and patient-derived products.
View Article and Find Full Text PDFAs a novel emerging technology, four-dimensional (4D) printing allows the stimulation of 3D-printed materials in order to change shape, color, functionality, etc, over time. This systematic review is conducted to evaluate the purpose, materials, physiomechanical, and biological properties of 4D-printed scaffolds used for bone tissue engineering. An electronic search was conducted following the PRISMA 2020 guidelines in PubMed, Scopus, Web of Science, and Google Scholar online databases limited to English articles until April 2024.
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- Vascularization is essential for bone tissue engineering, as it supports cell survival and tissue regeneration; however, strategies must be implemented to promote blood vessel formation.
- The study investigates the effectiveness of pre-vascularized gelatin-coated β-tricalcium phosphate (G/β-TCP) scaffolds in promoting bone and blood vessel growth, using both in vitro tests and a canine model.
- Results show promising initial findings with good cell adhesion and proliferation on scaffolds, successful angiogenesis in tissue samples, and scaffold resorption, though further optimization is required for effective bone regeneration in vivo.
Physicochemical and Biological Characterization of Gelatin/Alginate Scaffolds Reinforced with -TCP, FDBA, and SrHA: Insights into Stem Cell Behavior and Osteogenic Differentiation.
Int J Biomater
August 2024
Bone tissue engineering necessitates the development of scaffolds with optimal properties to provide a suitable microenvironment for cell adhesion, proliferation, and osteogenic differentiation. The selection of appropriate scaffold materials remains a critical challenge in this field. In this study, we aimed to address this challenge by evaluating and comparing the performance of hydrogel scaffolds reinforced with -tricalcium phosphate (-TCP), allograft, and a combination of allograft and strontium hydroxyapatite (SrHA).
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