High-numerical-aperture and high-efficiency polarization-based metalenses with pitch size control utilizing silicon-rich nitride.

This study investigates the role of pitch size in achieving high numerical aperture (NA) and focusing efficiency in metalens design, while demonstrating how high refractive index materials contribute to performance enhancement by enabling smaller pitch sizes through reduced filling ratios. Silicon-rich nitride (SRN) was chosen as the material platform due to its high refractive index, CMOS compatibility, and cost-effective fabrication. Two SRN-based metalenses were designed: a geometric phase metalens (GPM) and a propagation phase metalens (PPM), each evaluated at aspect ratios of 10:1 and 4:1.

Surface mold brachytherapy for head and neck non-melanoma skin cancer - local control rates and survival: A retrospective analysis.

Purpose: Non-melanoma skin cancer (NMSC) is the most prevalent cancer worldwide, particularly affecting head and neck region. Surgical excision, especially Moh's microsurgery, is the gold standard for treatment. However, certain patients' factors, such as age, comorbidities, and tumor location, require alternative therapies.

Postoperative NEOadjuvant TEMozolomide followed by chemoradiotherapy versus upfront chemoradiotherapy for glioblastoma multiforme (NEOTEM) trial: Interim results.

Background: Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor survival rates despite current treatments. The standard of care (SOC) includes surgery, followed by radiotherapy plus concurrent and adjuvant chemotherapy with temozolomide (TMZ). This phase II trial assessed the safety and efficacy of neoadjuvant TMZ (nTMZ) before and during chemoradiotherapy in newly diagnosed GBM patients.