Publications by authors named "A Khadwal"
Introduction: The gut microbiome has an established role in allogeneic hematopoietic cell transplantation (allo-HCT), but not in an auto-HCT setting. We have hypothesized that fecal short-chain fatty acids (SCFA) and urinary 3-indoxyl sulfate (3-IS), which are metabolites derived from the action of the gut microbiome on dietary fiber, play a role in auto-HCT outcomes.
Methods: This was a single-center prospective study involving auto-HCT recipients.
Introduction: The first-line treatment of moderate-severe chronic graft versus host disease (cGVHD) involves systemic corticosteroids ± calcineurin inhibitors. Around half of the patients will need second-line agents for corticosteroid-refractory/dependent (SR/SD) cGVHD. Herein, we report our experience using sirolimus as an add-on agent to corticosteroids in moderate-severe cGVHD.
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- There is a growing number of cancer cases prompting research into its causes, which has led to new targeted immunotherapy strategies that aim to reduce the negative effects of traditional chemotherapy and radiotherapy.
- Various targeted immunotherapies have been tested for their effectiveness, such as vaccines that use specific tumor-related antigens, checkpoint blockade therapies involving monoclonal antibodies, and adoptive cell transfer methods like CAR-T cell therapies.
- The text reviews recent progress in these targeted immunotherapeutic strategies while also discussing their limitations in treating cancer.
Purpose: Epstein-Barr virus (EBV) reactivation in allogeneic hematopoietic stem cell transplantation (allo-HCT) recipients can lead to significant complications including post-transplant lymphoproliferative disease. Despite progress in managing EBV reactivation in allo-HCT recipients, data on clinical characteristics and prognostic implications of EBV viral load remain limited. Here, we aim to evaluate the prevalence, identify risk factors, and assess the clinical implications of EBV-DNA positivity in allo-HCT recipients.
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