Comparative characteristics of genetic aberrations in glioblastomas in children and adults.

Glioblastomas in children and adults are a heterogeneous group of tumors that can be divided into at least three different subgroups: pediatric glioblastomas, IDH1-mutant glioblastomas in adults (the most favorable prognostic subtype), and IDH1-wild type glioblastomas in adults. According to the frequency of detected cytogenetic aberrations (amplification of the MYC/MYCN, EGFR and PDGRFA oncogenes, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene), pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults.

[Cytogenetic aberrations in histologically benign infiltratively growing sphenoid wing meningiomas].

Meningiomas of the sphenoid wing (SW) frequently show an invasive pattern of growth and cause destruction of the adjacent structures. As a result, the rate of recurrent SW meningiomas is as high as 30%. Cytogenetic investigations showed no aberrations specific to invasively growing meningiomas.

[Meningiomas: anatomical pathology and molecular biology].

In the past 5-10 years, there has been a considerable progress the understanding of the biology of meningioma. The most important advances have been made by comprehensive studies of the pathogenesis of meningioma in molecular genetics. Several target genes could be identified for mutation or inactivation.

[Experience in using a molecular resonance coagulator in neurooncology].

The paper analyzes the experience gained in using a molecular resonance coagulator in 145 patients with tumors of the base of the skull and brain. The Vesalius NEUROsurgery N1 molecular resonance apparatus is an innovational bipolar device that is specially designed for neurosurgical application,(operations on the brain). Due to the fact that the temperature at the site of a cut does not exceed 45-50 degrees C, the apparatus has the minimum effect on tissues, nerves, nerve ending, and blood vessels, permitting a surgeon to make interventions into sophisticated anatomic formations.

[Skull base meningiomas spreading into the infratemporal fossa: clinical picture, diagnosis, and treatment policy].

From 1997 to 2004, the Academician N. N. Burdenko Research Institute of Neurosurgery has operated on 54 patients with intracranial meningiomas spreading into the infratemporal fossa.