Publications by authors named "A Kh Akhmedov"
Background: Presentations and outcomes of acute myocardial infarction (MI) differ between women and men, with the worst outcomes being reported in younger women. Mental stress induced ischemia and sympathetic activation have been suggested to play a prominent role in the pathogenesis of MI in younger women, however, the impact of sex hormones on these parameters remains unknown.
Methods: The effect of sex hormones and age on myocardial infarct size and myocardial sympathetic activity (MSA) was assessed in male and female, as well as young (4-6 months) and aged (20-22 months) FVB/N mice (n = 106, 60 gonadectomized and 46 sham-operated animals) who underwent in vivo [C]meta-hydroxyephedrine ([C]mHED) positron emission tomography (PET) and cardiac magnetic resonance (CMR) imaging 24 h after a 30 min myocardial ischemic injury.
Background: Continuously improving cancer-specific survival puts a growing proportion of cancer patients at risk of major adverse cardiovascular events (MACE), but tailored tools for cardiovascular risk prediction remain unavailable.
Objectives: To assess a broad panel of cardiovascular biomarkers and risk factors for the prediction of MACE and cardiovascular death in cancer patients.
Methods: In total, 2192 patients with newly diagnosed or recurrent cancer were followed prospectively for the occurrence of 2-year MACE and 5-year cardiovascular death.
Background And Aims: Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction and tubular damage. This study examined the predictive value of PENK for renal outcomes and mortality in patients with acute coronary syndrome (ACS).
Methods: Proenkephalin was measured in plasma in a prospective multicentre ACS cohort from Switzerland (n = 4787) and in validation cohorts from the UK (n = 1141), Czechia (n = 927), and Germany (n = 220).
Giant cervical lipoma adjacent to carotid artery: a case report and literature review.
Zh Vopr Neirokhir Im N N Burdenko
August 2024
Article Synopsis
- Cervical lipomas that compress neurovascular structures are very rare and usually require surgical removal, particularly when they cause symptoms like dysphagia or breathing difficulties.
- A case study presented a 57-year-old patient who had a large cervical lipoma that compressed the oropharynx and esophagus, necessitating a gross total resection while carefully navigating important nerves and blood vessels.
- Post-surgery, the patient saw improvement in symptoms and was discharged after four days, highlighting that such surgical procedures, though complex, can successfully minimize complications in specialized medical centers.
Article Synopsis
- - Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder caused by a mutation in the lamin A gene (LMNA), leading to premature aging and increased risk of cardiovascular events in affected children.
- - Research using Lmna mutant mice showed that these animals formed blood clots more quickly than normal mice, with higher platelet activation and altered factors involved in blood clotting.
- - The study suggests that the LMNA mutation contributes to faster thrombus formation due to enhanced platelet reactivity, highlighting the need for further research on antiplatelet treatments for children with HGPS to reduce their risk of cardiovascular complications.