Publications by authors named "A Keyhani"
Article Synopsis
- Patients with chronic progressive external ophthalmoplegia (CPEO) are frequently misdiagnosed with congenital ptosis or ocular myasthenia gravis, often leading to unnecessary surgical procedures before receiving the correct diagnosis.
- A study of 32 CPEO patients revealed an average diagnostic delay of about 25 years, with many having undergone multiple eyelid surgeries prior to CPEO confirmation.
- Emphasizing the importance of early family history review and awareness of other CPEO symptoms could help reduce the rate of misdiagnosis and improve timely intervention.
Currently, no safe vaccine against leishmaniasis is available. So far, different control strategies against numerous reservoir hosts and biological vectors have not been environment-friendly and feasible. Hence, employing medicinal components and conventional drugs could be a promising approach to developing novel therapeutic alternatives.
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- * Experiments showed that the combination of 6-shogaol and MA has multiple beneficial effects, including strong leishmanicidal activity, antioxidant benefits, and promotion of immune responses.
- * Findings indicate that 6-shogaol enhances nitric oxide production and affects cell division and apoptosis in leishmaniasis-infected cells, paving the way for further research on these treatments.
Article Synopsis
- The study evaluated the expression of specific genes in different regions (protoscoleces, germinal layer, neck, and sucker) of adult parasites, aiming to understand their role in development.
- Conducted at Kerman University in 2018, researchers cultured protoscoleces to obtain strobilated worms, isolated various regions for analysis, and used RT-qPCR and immunohistochemistry for gene expression profiling.
- Results indicated that certain gene expressions varied significantly across different regions, suggesting their potential role in the differentiation of the parasite throughout its life cycle.