Publications by authors named "A Kettani"
Squalene synthase (SQS) plays a crucial role in the cholesterol biosynthetic pathway. Its distinctive strategic position makes it a promising candidate for targeting and developing new anti-hypercholesterolemic agents. To uncover novel phytochemical scaffolds as potential inhibitors of SQS, we employed a structure-based virtual screening approach that involves screening 545 phytochemicals collected from Moroccan aromatic and medicinal plants and filtering them based on RMSD values and their affinity towards the target enzyme.
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- - The study aimed to evaluate how acceptable, usable, and feasible HIV self-testing is among key populations in Morocco, particularly focusing on female sex workers, men who have sex with men, and partners of newly diagnosed individuals.
- - A total of 3,465 individuals were involved, with high acceptability rates for self-testing reported (90.2% among female sex workers, 86.2% among men who have sex with men). However, many participants (44.0% to 73.4%) had never been tested for HIV before.
- - The results suggest that expanding access to HIV self-testing can be beneficial for key populations in Morocco and potentially in other Middle Eastern and North African countries as well. *
Unlocking Benzosampangine's Potential: A Computational Approach to Investigating, Its Role as a PD-L1 Inhibitor in Tumor Immune Evasion via Molecular Docking, Dynamic Simulation, and ADMET Profiling.
Bioinform Biol Insights
November 2024
Article Synopsis
- The interaction between PD-1 and PD-L1 is key for tumor immune evasion and represents a target for cancer immunotherapy, though current treatments face issues such as high costs and resistance.
- Benzosampangine emerged from screening 511 natural compounds as a promising PD-L1 inhibitor, exhibiting strong binding affinity compared to existing controls and showcasing unique interactions with key amino acids in the active site.
- ADMET profiling indicates that benzosampangine has advantages over control molecules in terms of solubility, permeability, and low toxicity, supporting its potential use in therapies targeting the PD-1/PD-L1 pathway.
Introduction: Nutrition plays an integral role in optimizing football players' performance during training sessions and matches and maintaining their overall health throughout the season. This study aimed to evaluate how well the dietary practices of professional and adolescent football players in Morocco during the competitive period met international macronutrient recommendations, and to explore the relationship between their nutritional status and aerobic performance, as measured by the Yo-Yo IRL1 test.
Methods: A total of 277 footballers from Morocco's professional league, "Botola-Pro", were monitored over a seven-day (training microcycle) during the competitive period.
This study examines the effects of environmental conditions on venom production in four prevalent scorpion species in Morocco: Androctonus amoreuxi, Androctonus mauretanicus, Buthus mardochei, and Scorpio maurus. The research focuses on how climatic factors such as temperature, humidity, and diet-specifically mealworm consumption-affect physical parameters including size and weight, and ultimately venom yield. We conducted a comprehensive investigation involving the capture, acclimatization, and systematic venom extraction from 480 scorpions.
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