Publications by authors named "A Kawata"
Introduction: Bowel urgency has recently been recognized as a Crohn's disease (CD) symptom that substantially impacts patients' quality of life. The Urgency NRS is a single-item patient-reported outcome measure assessing bowel urgency severity in the past 24 h (0-10 scale). We aimed to evaluate the psychometric properties of the Urgency Numeric Rating Scale (NRS) in adults with moderately to severely active CD and to estimate thresholds for meaningful improvement and bowel urgency remission.
View Article and Find Full Text PDFArticle Synopsis
- Aberrant light/dark cycles from electric light usage can disrupt circadian rhythms, leading to mood disorders, but research on physiological effects is limited.
- An experiment on male Wistar rats showed that long light phases (20L:4D) led to decreased body temperature and activity rhythms, while long dark phases (4L:20D) caused circadian misalignment, both resulting in increased body weight.
- Changes in neurotransmitter levels were observed in specific brain areas, and both extreme light/dark cycles caused anxiety-like behaviors in the rats, indicating that these cycles can negatively impact mood and behavior.
Purpose: To provide further evidence on the psychometric properties of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) in moderately to severely active Crohn's disease (CD), and to determine thresholds for meaningful improvement in fatigue.
Methods: The FACIT-Fatigue is a 13-item patient-reported outcome measure (range, 0-52) assessing fatigue over the previous week. Using pooled data from the Phase 3 VIVID-1 study of moderately to severely active CD, psychometric properties of FACIT-Fatigue were evaluated up to Week 52.
Article Synopsis
- - The study aimed to create a CT-based deep learning model for distinguishing low-risk and high-risk thymoma, comparing its performance with that of radiologists.
- - A total of 159 patients were analyzed using a fine-tuned VGG16 model with various data augmentations, resulting in a DL accuracy of 71.3%.
- - While the DL model improved diagnostic accuracy for radiologists, the overall performance, gauged by the area under the curve (AUC), showed no significant differences with or without the model.
We describe the case of a 70-year-old Japanese man with familial amyotrophic lateral sclerosis (fALS) associated with a p.Gly93Ser mutation in the copper/zinc superoxide dismutase (SOD1) gene. This mutation is one of the relatively rare SOD1 mutations, with only one previous autopsy report, and is known for its longer disease duration.
View Article and Find Full Text PDF