Publications by authors named "A Kawano-Nagatsuma"
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, and tumor metastasis is the leading cause of death. Targeting immune inhibitory checkpoint inhibitory pathways has attracted great attention, since the therapeutic efficacy induced by the specific blocking antibodies has been demonstrated even in metastatic CRC patients. However, the clinical outcome is low in many cases, and thus more effective treatments are needed in the clinical settings.
View Article and Find Full Text PDFAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFArticle Synopsis
- A custom oligonucleotide array was developed to analyze 394 genes linked to cancer, with a focus on SEC11A, which encodes the SPC18 protein, and its expression examined in gastric cancer tissue samples.
- SPC18 protein levels were evaluated through immunohistochemistry in two different cohorts, revealing that a significant percentage of gastric cancer cases had overexpression related to poorer survival outcomes.
- Functional experiments showed that increased SPC18 levels promote gastric cancer cell growth and TGF-α secretion, suggesting its role in malignant progression.