Publications by authors named "A Kawana"
Durvalumab plus platinum-based chemotherapy is the first-line treatment for extensive-stage small-cell lung cancer. Immune checkpoint inhibitors (durvalumab) can cause immune-related adverse events (irAEs). We herein report the first case of fatal sepsis with anti-interleukin-6 autoantibody production following durvalumab administration.
View Article and Find Full Text PDFBackground: Aspergillus fumigatus is a pathogenic fungus known to be associated with severe asthma and allergic bronchopulmonary mycosis. However, the precise mechanisms underlying airway inflammation remain unclear. In this study, we investigated the direct modulation of human eosinophils by A.
View Article and Find Full Text PDFArticle Synopsis
- - Relapsing polychondritis (RP) is a rare autoimmune disorder that causes inflammation and damage to cartilage in the body.
- - The text reports an association between COVID-19 vaccination and the onset of RP, highlighting a possible side effect of the mRNA vaccines.
- - It emphasizes the need for healthcare providers to be aware that RP could emerge as a complication following vaccination against COVID-19.
C-X-C motif chemokine ligand 14 (CXCL14) is expressed in the airway epithelial cells of patients with asthma. However, the mechanisms of CXCL14 secretion and its effects on asthma pathogenesis remain unclear. Here, we investigated the role of CXCL14 in allergic airway inflammation and its effects on eosinophil infiltration.
View Article and Find Full Text PDFBackground: Clinical studies have demonstrated that IL-4, a type 2 cytokine, plays an important role in the pathogenesis of chronic rhinosinusitis and eosinophilic asthma. However, the direct effect of IL-4 on eosinophils remains unclear.
Objective: We aimed to elucidate the inflammatory effects of IL-4 on the functions of human eosinophils.