Publications by authors named "A Katzer"
Article Synopsis
- The threespine stickleback iridovirus (TSIV) is identified as a double-stranded DNA virus and the first of its kind found in North American wild fish, with a new occurrence reported in sticklebacks from Stormy Lake, Alaska.
- Researchers assembled a nearly complete 115-kilobase genome of TSIV, revealing 94 open reading frames (ORFs), mostly similar to other iridoviruses, and some likely acquired through lateral gene transfer.
- A significant prevalence of TSIV was observed in sticklebacks prior to a rotenone treatment aimed at controlling invasive fish, with a complete absence of the virus found in the population two years later, indicating a strong association between the treatment and the
In the formation of species, adaptation by natural selection generates distinct combinations of traits that function well together. The maintenance of adaptive trait combinations in the face of gene flow depends on the strength and nature of selection acting on the underlying genetic loci. Floral pollination syndromes exemplify the evolution of trait combinations adaptive for particular pollinators.
View Article and Find Full Text PDFBackground: Radiotherapy is routinely used to combat glioblastoma (GBM). However, the treatment efficacy is often limited by the radioresistance of GBM cells.
Methods: Two GBM lines MO59K and MO59J, differing in intrinsic radiosensitivity and mutational status of DNA-PK and ATM, were analyzed regarding their response to DNA-PK/PI3K/mTOR inhibition by PI-103 in combination with radiation.
Background: Although total knee arthroplasty (TKA) procedures are increasing, patient satisfaction is still inferior compared to total hip arthroplasty. The ATTUNE Knee System was designed to reduce pain and improve function, leading to greater patient satisfaction and decreased resource utilization in TKA. The objective of this study was to compare length of stay (LOS) of TKA with ATTUNE knee versus LCS knee implants.
View Article and Find Full Text PDFBackground: Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, we explore the impact of the Akt inhibitor MK-2206 alone and in combination with the dual PI3K and mTOR inhibitor PI-103 on the radiation sensitivity of glioblastoma cells.
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