Publications by authors named "A Kasuga"
Background: Although cisplatin plus gemcitabine and other combinations have improved the survival of advanced biliary tract cancer (BTC), high unmet medical needs remain. This study aimed to assess the efficacy and safety of nivolumab plus lenvatinib in the second-line treatment for advanced BTC.
Patients And Methods: Nivolumab (240 mg) was administered biweekly.
Article Synopsis
- * A study involving ten patients examined the drug's efficacy over six months, finding a significant reduction in HbA1c levels from 8.1% to 6.9%, indicating improved blood sugar control.
- * The study also noted no negative impact on kidney function and some improvement in liver conditions, suggesting overall health benefits; however, more research is needed to assess its long-term effects.
Background: Stent migration and sludge formation remain significant problems associated with covered self-expandable metal stents (CSEMSs). The EGIS biliary stent fully covered flare type (EGIS biliary stent), a new type of polytetrafluoroethylene-coated self-expandable metal stent with low axial force and an anti-migration system, was developed to overcome these disadvantages. We conducted this study to evaluate the efficacy and safety of this stent in comparison with conventional CSEMS (c-CSEMS).
View Article and Find Full Text PDFLiver Oligometastasis in Biliary Tract Cancer and Impact on Survival Outcomes.
J Gastrointest Cancer
December 2024
Article Synopsis
- This study assessed the outcomes of biliary tract cancer (BTC) patients with liver metastases who received chemotherapy, revealing unclear survival characteristics based on liver involvement.
- The research included 96 patients, showing those with only liver metastases had better overall survival (11.8 months) compared to those with multiple organ involvement (7.4 months).
- Key findings indicated that patients with fewer liver metastases (oligometastases) had a longer survival rate, especially benefiting from subsequent surgery, suggesting a potential treatment path for better outcomes in selected cases.
Aim: This study aims to identify the key risk factors that lead to subtypes of physical frailty assessed by walking speed and grip strength among community-dwelling Japanese individuals, stratified by the presence of musculoskeletal diseases (MSDs) and age group.
Methods: We included 302 participants aged 70 or 80 years who did not exhibit subtypes of physical frailty at baseline through the Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians (SONIC) study. Our study was a longitudinal study.