Publications by authors named "A Karyoti"
Effects of an Active Surveillance Program and Enhanced Infection Control Measures on Carbapenem-Resistant Gram-Negative Bacterial Carriage and Infections in Pediatric Intensive Care.
Microb Drug Resist
November 2019
We evaluated the effects of enhanced infection control measures (ICMs) on carriage and infections of carbapenem-resistant Gram-negative bacteria (CRGNB) in a pediatric intensive care unit. We conducted a quasi-experimental study, including patients with infections of CRGNB retrospectively for 13 months and those participating in an active surveillance program prospectively for 22 months. Active surveillance (weekly rectal swabs) was implemented during a 63-week subperiod with standard ICMs and a subsequent 27-week subperiod with enhanced ICMs (intensified ICMs supplemented with audits and feedback).
View Article and Find Full Text PDFObjectives: The aim of this study was to forecast the monthly incidence rates of infections [infections/1000 bed-days (IBD)] due to carbapenem-resistant Klebsiella pneumoniae (CRKP), carbapenem-resistant Pseudomonas aeruginosa (CRPA), carbapenem-resistant Acinetobacter baumannii (CRAB) and total carbapenem-resistant Gram-negative bacteria (CRGNB) in an endemic intensive care unit (ICU) during the subsequent year (December 2016-December 2017) following the observational period.
Methods: A 52-month observational period (August 2012-November 2016) was used. Two forecasting models, including a simple seasonal model for CRGNB, CRKP and CRPA and Winters' additive model for CRAB infections, were applied.
Comparison of semiquantitative and differential time to positivity methods for the diagnosis of central line-associated bloodstream infections in an intensive care unit.
Access Microbiol
June 2019
Article Synopsis
- - The study investigates two methods for diagnosing central line-associated bloodstream infections (CLABSIs) in ICU patients: semiquantitative roll plate (SQRP) and differential time to positivity (DTP).
- - SQRP showed high sensitivity (94.7%), while DTP had high specificity (82.5%), and together they achieved 100% sensitivity and negative predictive value.
- - The results suggest that employing both SQRP and DTP methods in tandem could improve the diagnostic accuracy for CLABSIs.
We report a predominance (64.7%) of polyclonal carbapenem-resistant Acinetobacter baumannii (CRAB) strains concurrently producing OXA-23 and OXA-58 carbapenemases in a pediatric intensive care unit in an endemic area. This is the first report of emergence of such double-OXA CRAB strains in a single unit worldwide.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on the molecular epidemiology of carbapenem-resistant bacteria (CRKP, CRPA, and CRAB) in a high-resistance intensive care unit.
- - A new strain of CRPA was identified that produces both VIM and KPC enzymes, marking the first detection of this combination in an endemic region.
- - CRKP strains, mainly from the "hyperepidemic Greek clone," were the most prevalent, while CRAB strains producing OXA-23-like enzymes displayed various pulsotypes.