Publications by authors named "A Kartolo"
Background: Head and squamous cell carcinoma (HNSCC) in the locally advanced setting is challenging to treat and remains an area of significant morbidity and mortality. For patients who are cisplatin-ineligible and considered unresectable, there is no clear standard of care including the choice of radiosensitizer.
Methods: OVID Medline, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched.
Article Synopsis
- About 30% of people with non-small cell lung cancers (NSCLC) have stage III cancer when they find out they're sick, and half of them get treated with special chemotherapy and radiation.
- A study looked at 195 patients treated from 2010 to 2021 to see what factors affect their chances of getting brain cancer after treatment.
- Out of these patients, many had complications; 43% got any kind of cancer spread and 17% developed brain cancer, especially if they had more severe disease or certain treatment-related factors.
Article Synopsis
- The study investigates how the timing of immune checkpoint inhibitors (ICIs) affects patient outcomes in advanced melanoma.
- Patients who received all their initial ICI infusions in the afternoon showed significantly worse overall and progression-free survival compared to those who had at least one morning infusion.
- A recommendation is made that scheduling ICI treatments in the morning could potentially improve survival rates for patients.
The aim of this study was to evaluate overall survival post-treatment discontinuation survival (OS PTD ) in advanced melanoma patients started on immunotherapy. This retrospective study included all unresectable advanced or metastatic melanoma patients who had permanent treatment discontinuation after receiving at least one cycle of palliative-intent programmed death-1 ± cytotoxic T-lymphocyte associated protein-4 inhibitor treatment from 2014 to 2019. Indications of permanent treatment discontinuation included treatment completion, toxicity or progression.
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