Publications by authors named "A Karki"
Background: The neural bases of decision-making and contextual sensory discriminations have traditionally been studied in primates, highlighting the role of the prefrontal cortex in cognitive control and flexibility. With the advent of molecular tools to manipulate and monitor neuronal activity, these processes have increasingly been studied in rodents. However, rodent tasks typically consist of two-alternative forced choice paradigms that usually feature coarse sensory discriminations and no contextual dependence, limiting prefrontal involvement in task performance.
View Article and Find Full Text PDFPurpose: This phase II study evaluated the efficacy and tolerability of onvansertib, a polo-like kinase 1 (PLK1) inhibitor, in combination with fluorouracil, leucovorin, and irinotecan (FOLFIRI) + bevacizumab for the second-line treatment of -mutant metastatic colorectal cancer (mCRC).
Patients And Methods: This multicenter, open-label, single-arm study enrolled patients with -mutated mCRC previously treated with oxaliplatin and fluorouracil with or without bevacizumab. Patients received onvansertib (15 mg/m once daily on days 1-5 and 15-19 of a 28-day cycle) and FOLFIRI + bevacizumab (days 1 and 15).
spp. constitute a group of microaerophilic bacteria that includes strains that are aerotolerant and capable of surviving in aerobic conditions. Recent studies have shown that aerotolerant strains are highly prevalent in meats, animals, and clinical settings.
View Article and Find Full Text PDFArticle Synopsis
- The One Health (OH) approach to combat antimicrobial resistance (AMR) is gaining recognition, but there’s a lack of clear guidance on implementing effective surveillance across different sectors.
- In Nepal, the Tricycle Project utilized a multi-stage method to collect samples from humans, poultry, and wastewater to assess the prevalence of ESBL-producing bacteria.
- The study found the highest prevalence of ESBL-producing bacteria in wastewater (91%), followed by bloodstream infections in humans (49%), poultry (38.6%), and healthy pregnant women (15%), leading to important insights for improving waste disposal and AMR control strategies.
Article Synopsis
- Human-wildlife conflicts in western Nepal, particularly involving elephants, leopards, and tigers, lead to human casualties and a negative perception of conservation efforts.
- A study analyzed 76 incidents of human deaths and injuries from 2019 to 2023, finding that tigers were responsible for 75% of attacks, predominantly occurring near forest edges during the day.
- To improve coexistence, strategies such as community patrols, habitat restoration, electric fencing, and insurance for local farmers were recommended to mitigate future conflicts.