Publications by authors named "A Kargi"
Article Synopsis
- Carbamoyl phosphate synthetase 1 (CPS-1) deficiency is a rare urea cycle disorder affecting approximately 1 in 150,000-200,000 newborns, often causing severe hyperammonemia shortly after protein intake, leading to high mortality rates in early-onset cases.
- A case study of a newborn male with elevated ammonia levels due to CPS-1 deficiency shows he received urgent treatments, including dextrose infusion, ammonia-scavenging therapy, peritoneal dialysis, and ultimately, a liver transplant from his father at six months of age.
- The study highlights the potential benefits of liver transplantation in CPS-1 deficiency cases and suggests that carglumic acid could improve long-term
Objective: To evaluate the efficacy and safety of nivolumab in the second-line (2L) or later-line (LL) treatment of patients with locally advanced/metastatic non-small cell lung cancer (NSCLC) in real-life setting in Türkiye.
Methods: This study was designed as a national, multi-center, retrospective study. The study population was evaluated in two groups for the line of nivolumab therapy: those receiving nivolumab in the 2L (Group 2L) and third-line (3L) or LL (Group 3L/LL).
The high prevalence of thyroid nodules and increased availability of neck ultrasound have led to an increased incidence of diagnostic thyroid fine needle aspirations, with approximately 20% yielding indeterminate results. The recent availability of molecular tests has helped guide the clinical management of these cases. This paper aims to review and compare three main commercially available molecular cytology platforms in the U.
View Article and Find Full Text PDFImpact of long-acting growth hormone replacement therapy in adult growth hormone deficiency: Comparison between adolescent, adult, and elderly patients.
Best Pract Res Clin Endocrinol Metab
December 2023
The predominant features of the adult growth hormone deficiency (GHD) syndrome may vary between patients of different age and age of onset of GHD. Evidence from clinical trials and long-term observational studies has informed our ability to understand the unique considerations regarding risks and benefits of daily growth hormone replacement therapy (GHRT) and specific dosing and monitoring strategies for these patient subgroups. High rates of nonadherence with daily GHRT presents a challenge to achieving optimal treatment outcomes and long-acting growth hormone (LAGH) formulations have been developed with the promise of improving treatment adherence resulting in improved therapeutic outcomes.
View Article and Find Full Text PDFBackground: The expanded polytetrafluoroethylene (ePTFE) grafts are used to drain anterior sector veins during the living donor liver transplantation procedure. We aimed to analyze the potentially life-threatening complications, such as the infection and migration of ePTFE grafts.
Methods: A total of 1264 liver transplantations (LTs) were performed for 1097 adult and 167 pediatric liver failure cases.