Publications by authors named "A Kardinaal"

Numerous studies have established that prebiotic ingredients in foods and dietary supplements may play a role in supporting human health. Over the three decades that have passed since prebiotics were first defined as a concept, research has revealed a complex universe of prebiotic-induced changes to the human microbiota. There are strong indications of a direct link between these prebiotic-induced changes and specific health benefits.

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Article Synopsis
  • The clinical study investigated the effects of LifeinU™ Bacillus subtilis CU1 (BSCU1) on immune responses in 88 participants across different age groups, aiming to understand how it might improve protection against infections.
  • Although BSCU1 did not significantly alter fecal sIgA levels, it positively impacted various markers of the innate immune system, especially in adults and the elderly, by increasing peripheral blood myeloid cells and CD69 expression on monocytes.
  • Additionally, the supplementation led to higher production of pro-inflammatory cytokines and improved the ability of monocytes to engulf bacteria, while also reducing levels of certain inflammatory cytokines in older adults, suggesting potential benefits for overall immune health.
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Bovine milk contains bioactive proteins, carbohydrates, and phospholipids with immunomodulatory properties impacting human immunity, potentially contributing to resistance to infections and allergies through diverse mechanisms. One such mechanism is the enhancing of the innate immune response to secondary pathogen-related stimuli, termed innate immune training. Although studies demonstrate that milk immunoglobulin G (IgG) can train human monocytes, evidence for immune training is limited.

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To identify the potential anabolic properties of a dairy-plant protein blend as compared to single plant-based and single dairy protein, the postprandial amino acid (AA) response of pea protein, milk protein, micellar casein, and a casein-pea protein blend was investigated in healthy older adults (age 72.3 ± 3.4 years, BMI 25.

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It is crucial for human health that the immune system of the gastrointestinal tract works effectively. Dietary modulation is one of the factors that regulate the immune response in the gut. This study aims to develop a safe human challenge model to study gastrointestinal inflammation and immune function.

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