Manganese-Catalyzed Electrochemical Amination of Activated Alkenes.

We have unveiled a new manganese-catalyzed electrochemical amination method to transform activated alkenes into a diverse array of vinyl amines harnessing sodium azide as the aminating reagent. The strategy claims notable versatility by accommodating a broad spectrum of substrates, demonstrating good compatibility with diverse functional groups, as well as delivering a moderate to good range of yields. The successful late-stage functionalization further underscores its practical utility.

Smoking patterns and outcomes of severe sars-CoV-2 infection: a retrospective cohort study.

The purpose of this study was to analyze the association between the number of cigarettes smoked and the length of smoking with mortality among patients who were hospitalized in the intensive care unit (ICU) due to SARS-CoV-2 infection. This retrospective cohort study was conducted at the General Hospital in Sombor (Serbia). Patients who were hospitalized because of severe SARS-CoV-2 infection between March 2021 and March 2023 were included in this study.

All-at-once RNA folding with 3D motif prediction framed by evolutionary information.

Structural RNAs exhibit a vast array of recurrent short 3D elements involving non-Watson-Crick interactions that help arrange canonical double helices into tertiary structures. We present CaCoFold-R3D, a probabilistic grammar that predicts these RNA 3D motifs (also termed modules) jointly with RNA secondary structure over a sequence or alignment. CaCoFold-R3D uses evolutionary information present in an RNA alignment to reliably identify canonical helices (including pseudoknots) by covariation.