Publications by authors named "A Karak"
Hypochlorite, as an important reactive oxygen species (ROS), plays a vital role in many physiological and pathological processes, but an excess concentration of hypochlorite (ClO) may become toxic to humans and cause disease. Hence, the selective and rapid detection of hypochlorite (ClO) is necessary for human safety. Here, we report a novel near-infrared (NIR) fluorescence "turn-on" and highly selective benzophenoxazinium chloride-based fluorescent probe, (benzophenoxazinium dihydroxy benzaldehyde), for hypochlorite detection.
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- Phosgene, diphosgene, and chlorine are highly toxic choking agents that can cause serious respiratory issues, including death, leading to the development of small-molecule fluorescent probes for safe detection.
- Two designed probes, TCAO and HMBT, were evaluated, with TCAO showing greater selectivity and sensitivity for phosgene detection due to its electron-donating group.
- TCAO was further studied, revealing a significant increase in its quantum yield upon phosgene exposure and achieving a detection limit of 51 nm, with a user-friendly paper-strip method for onsite monitoring.
In the current situation, peroxynitrite (ONOO) is drawing the increasing attention of researchers for its pivotal role in diverse pathological and physiological processes on grounds of robust oxidation and nitrification. Herein, we have successfully designed and synthesized a phenanthrenequinone benzyl borate-based chemosensor for fast and selective detection of ONOO. The probe itself had an orange fluorescence, which was changed to strong blue fluorescence upon the addition of ONOO, indicating the ratiometric response of the probe.
View Article and Find Full Text PDFNerve agents are among the most deadly and lethal chemical warfare agents (CWAs). Rapid identification is crucial for specialized individuals to take action against dangerous drugs. This paper describes the synthesis and characterisation of a probe (MNFZ) based on the methoxy naphthalene-furoic hydrazide group.
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- The study investigates how anionic polyamidoamine succinamic acid dendrimer (PAMAM-SA, G5) interacts with positively charged hybrid vesicles (HCV) made from soylecithin and other components, using various techniques like dynamic light scattering and microscopy.
- Results indicate that the dendrimer's effect on the vesicle's membrane stability varies with its concentration, with low concentrations preserving the membrane while higher levels cause disruption and formation of holes.
- In vitro tests show that the combination of dendrimer and HCV displays significant anticancer activity against breast cancer cells, suggesting potential for use in targeted drug delivery systems with minimal side effects.