J Eur Acad Dermatol Venereol
November 2024
The skin barrier can be divided into at least four functional units: chemical, microbial, physical and immunological barriers. The chemical and microbial barriers have previously been shown to exhibit different characteristics in topographically distinct skin regions. There is increasing evidence that the physical and immunological barriers also show marked variability in different areas of the skin.
View Article and Find Full Text PDFUnlabelled: Prognostic studies can provide important information about disease biology and improve the use of biomarkers to optimize treatment decisions.
Methods: A total of 199 patients with advanced melanoma treated with BRAF + MEK inhibitors were included in our single-center retrospective study. We analyzed the risk of progression and death using multivariate Cox proportional hazard models.
Background: Prognostic classification of metastatic melanoma patients treated with anti-PD-1 is of great interest to clinicians.
Objective: We aimed to determine the anti-PD-1 treatment related prognostic performance of demographics, clinical and histological prognostic markers and baseline serum S100B and LDH levels in advanced melanoma.
Methods: A total of 200 patients with unresectable metastatic melanoma were included in this retrospective study.