Fetal congenital heart diseases: Diagnosis by anatomical scans, echocardiography and genetic tests.

Objective: To determine the distribution of major fetal congenital heart diseases (CHDs) diagnosed antenatally during routine second-trimester obstetric anatomical scans in an unselected population at a single tertiary centre and to characterise and stratify risk factors, genetic diagnosis and long-term health at 4 years old.

Method: A single-centre cohort study of all major fetal CHDs detected on routine obstetric fetal anatomical ultrasound scans between January 2014 and December 2017 was performed in an unselected population. Demographic details, fetal echocardiogram reports, genetic test results, delivery outcomes and postnatal progress were stratified by CHD subtype.

COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection.

Objectives: To investigate multi-dose and timings of COVID-19 vaccines in preventing antenatal infection.

Design: Prospective observational study investigating primary vaccinations, boosters, antenatal COVID-19 infections, neutralizing antibody (Nab) durability, and cross-reactivity to Delta and Omicron variants of concern (VOCs).

Results: Ninety-eight patients completed primary vaccination prepregnancy (29.

Stress and burnout amongst mental health professionals in Singapore during Covid-19 endemicity.

The COVID-19 pandemic has exerted a huge emotional strain on mental health professionals (MHP) in Singapore. As Singapore transited into an endemic status, it is unclear whether the psychological strain has likewise lessened. The aims of this study were to investigate the levels of stress and burnout experienced by MHP working in a tertiary psychiatric hospital in Singapore during this phase of COVID-19 endemicity (2022) in comparison to the earlier pandemic years (2020 and 2021) and to identify factors which contribute to as well as ameliorate stress and burnout.

Isothermal Dual-Phase Flow Modeling to Assess the Impact of Gas Collection on Geotechnical and Hydraulic Performance of Landfills.

Liquid addition to landfilled municipal solid waste (MSW) is a practice employed to accelerate the biodegradation of the organic fraction of MSW and ensuing gas generation. Pore landfill gas (LFG) and leachate pressure from the added moisture and enhanced gas generation are expected to impact the geotechnical stability of landfill slopes. The impact of moisture addition and gas collection on the stability of landfills was numerically modeled using transient isothermal dual-phase flow and slope stability modeling.