Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts.

Fibrosis is one of the major outcomes following injury in the heart. Immune response in the injury niche modulates fibrosis, yet little is known about how cell-autonomous immune signaling in adult cardiac fibroblasts regulates fibrosis. Using FACS, single-cell sequencing of cardiac fibroblasts from Collagen1-α1GFP mice and human heart failure patients, we demonstrate that TLR4 is the major immune sensor expressed in cardiac fibroblasts.

Diagnostic Efficacy of Hysteroscopy and Its Use as a Therapeutic Aid in Perimenopausal and Postmenopausal Women - See and Treat.

Aim: The aim of this study was to study the therapeutic role of hysteroscopy in peri- and postmenopausal women in certain pathological conditions, where it can be done as a single-time procedure to diagnose and operate wherever needed and possible.

Objective: The objective of this study was to measure the diagnostic accuracy of hysteroscopy and its therapeutic efficacy in peri- and postmenopausal women.

Introduction: Hysteroscopy is one of the accurate diagnostic procedures in diagnosing the cause of peri- and postmenopausal bleeding (PMB).

Unveiling the Reactivity of Part Per Million Levels of Cobalt-Salen Complexes in Hydrosilylation of Ketones.

A series of air-stable cobalt(III)salen complexes Co-1 to Co-4 have been synthesized and employed in the hydrosilylation of ketones. Notably, the most intricately tailored Co-3 pre-catalyst exhibited exceptional catalytic activity under mild reaction conditions. The developed catalytic hydrosilylation protocol proceeded with an unusual ppm level (5 ppm) catalyst loading of Co-3 and achieved a maximum turnover number (TON) of 200,000.

Air-Stable Iron(III) Salen Complexes for Selective Hydroboration of Ketones and Unactivated Imines without Base Activation.

Herein, we designed and synthesized a series of air-stable, cost-effective, and readily synthesizable iron(III) salen complexes ( and ) for facilitating the selective hydroboration of ketones and unactivated imines with pinacolborane in the absence of any additive. These catalyst systems exhibited good yields, chemoselectivity, high atom economy, and a broad substrate scope under mild reaction conditions with a minimal catalyst loading of 0.2 mol %.

Evaluation of association between time in range, a continuous glucose monitoring metric, and cardiac autonomic neuropathy in type 2 diabetes patients.

Introduction: Time in range (TIR), a metric of continuous glucose monitoring (CGM) provides better information regarding the individual's glycemic variability than a static measure like glycated hemoglobin (HbA1c). TIR is emerging as an independent risk factor for diabetic complications, both microvascular and macrovascular complications independent of HbA1c. Hence, this study evaluates the association between TIR and cardiac autonomic neuropathy (CAN) in type 2 diabetic patients.