Non-mutagenicity of thiadiazole-1,3,4 derivatives in Salmonella typhimurium strains.

The Ames mutagenicity assay with Salmonella typhimurium strains (TA97a, TA98, TA100 and TA102) was used to investigate the ability of five dyes (thiadiazole-1,3,4 derivatives) to induce point mutations. The results did not reveal any mutagenic effects of the tested dyes on the S. typhimurium strains.

[Assessment of genotoxic activity of azo dye thiadiazole derivatives with the help of a structural chromosome aberration test].

The genotoxic activity of 2-methyl aminothiadiazole and azo dyes series of azo thiadiazole-1,3,4 was assessed using chromosome aberration in vivo and in vitro. The test in vivo was performed on mice bone marrow cells and in vitro on human blood lymphocytes. Derivatives of 2-naphthol, p-chlorophenol, pyro-catechin, resorcin and gamma resorcin acid were tested.