Publications by authors named "A Kalinska-Bienias"
Objective: In systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) cardiac involvement is very common, and it might be asymptomatic. We aimed to assess the presence of fragmented QRS (fQRS) - possible indicator of a scar, diffuse damage or conduction system disturbances in those patients.
Methods: We examined 74 patients with SSc, 77 with SLE and 40 healthy controls.
Autoimmune blistering disorders (AIBD) include a heterogeneous group of diseases characterized by the presence of autoantibodies against the structural antigens of the skin and mucous membranes. The gold standard of AIBD diagnostics is the detection of in vivo bound IgG/IgA and/or complement component 3 in the direct immunofluorescence of a perilesional biopsy. Various immunological techniques such as indirect immunofluorescence of different tissue substrates including monkey oesophagus, salt split skin, recombinant proteins of epidermis and basement membrane zone as well as ELISA systems and immunoblotting are used to characterize target antigens.
View Article and Find Full Text PDFIntroduction: The roles of galectin-3 (Gal-3) and galectin-3 binding protein (G3BP) in systemic lupus erythematosus (SLE) are of ongoing interest, but the data are insufficient due to highly limited available studies. There are no data on cutaneous lupus erythematosus (CLE).
Aim: To assess serum Gal-3 and G3BP concentrations in SLE patients with and without LE-specific skin lesions, CLE patients and to correlate levels of proteins with clinical and laboratory parameters.
Article Synopsis
- Bullous pemphigoid (BP) is a common autoimmune disease marked by skin blisters, with pruritus (itching) being a major symptom that hasn't been well studied.
- A study involving 32 newly diagnosed BP patients aimed to assess the characteristics of their itching using a questionnaire and visual analogue scale (VAS).
- Results showed that most patients experienced daily itching, particularly in the evening and at night, with significant aggravating factors like sweating and heat, while cold was the main relief. Itch intensity was moderate and did not correlate with the overall disease severity, indicating the need for better treatment options.
Background: Mucosal involvement in autoimmune subepidermal blistering disorders (ASBD) may represent the only or predominant localization. Circulating autoantibodies are detected in 50% cases.
Objective: The aim of this study was to evaluate the usefulness of fluorescence overlay antigen mapping by laser-scanning confocal microscopy (FOAM-LSCM) to identify ASBD with mucosal involvement in oral mucosa specimens.