Publications by authors named "A Kalhan"
Approved and Emerging Hormone-Based Anti-Obesity Medications: A Review Article.
Indian J Endocrinol Metab
September 2024
Obesity is a heterogeneous, complex, and chronic disease that has a detrimental impact on disability-adjusted life years across the globe. Recent advancements in our understanding of gut-brain communication at the molecular level have driven the development of next-generation anti-obesity medications (AOMs). Glucagon-like peptide-1 receptor agonists (GLP1RAs) remain the front-runners in this rapidly evolving landscape of hormone-based AOMs.
View Article and Find Full Text PDFThe GLOBICS-Global Consortium of Oral Health Birth Cohort Studies (OHBCS)-is a long-lasting international collaborative research group among existing OHBCS, established in response to the Lancet Series on Oral Health, which pointed out the need to shift the global oral health agenda. This study aimed to identify priority research questions from OHBCS that can be leveraged to improve children's global oral health. A 2-phase online Delphi process sought consensus over research priorities for OHBCS.
View Article and Find Full Text PDFAim: This study investigated the association between the triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, and moderate/severe periodontitis and the role of blood pressure as a mediator in this association. A second aim was to assess the role of cardiometabolic conditions such as obesity, hypertension, and dyslipidemia as potential effect modifiers.
Methods: Data from 5733 US adults aged 30-64 years and with complete periodontal examination were analyzed (NHANES 2011-2014).
Article Synopsis
- - Oral semaglutide was shown to improve cardiovascular risk factors in type 2 diabetes patients in a real-world setting, as evidenced by significant reductions in weight, blood pressure, and cholesterol levels over time.
- - A study involving 76 patients highlighted that the primary reasons for starting the medication were weight loss and improved blood sugar control, with positive results observed within 3-6 months and sustained improvements at the 6-12 month mark.
- - While 23.6% of patients discontinued the drug mainly due to gastrointestinal issues, there were no serious adverse events noted, supporting the medication's overall safety and effectiveness in this population.
Oral and systemic health in Singapore: Revisiting the past to define the future.
Community Dent Oral Epidemiol
June 2024
Objectives: This study aimed to identify studies exploring oral and systemic conditions using Singapore data.
Methods: Studies were searched using the databases PubMed, Embase and Web of Science, with no publication date or language restrictions. Studies analysing Singaporean data were included in this review.