Publications by authors named "A Kalayci"
Autism spectrum disorder (ASD) is a genetically heterogeneous neurobehavioral disorder. The etiology and the inheritance pattern are usually multifactorial. The index case is a 3-year-old male, whose family applied to the child psychiatry outpatient clinic due to failure to speak at 30 months.
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- Renal dysfunction is common in heart failure patients and linked to poor outcomes, but how cardiac structure and function impact kidney health remains unclear.
- This study analyzed data from the PARAGON-HF trial to explore the relationship between echocardiographic measurements of heart structure/function and changes in kidney function over time.
- Results showed that higher left ventricular mass and certain heart parameters are associated with greater declines in kidney function and an increased risk of serious kidney-related events, suggesting that cardiac health plays a crucial role in renal outcomes for these patients.
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- This study investigated DNA methylation levels in perimenopausal and postmenopausal women, focusing on the effects of hot flashes (HFs) on sleep parameters among 30 participants aged 45 to 55 with low cardiovascular risk.
- Two groups were formed: Group 1 with HFs present and Group 2 without; results showed that Group 1 had lower sleep efficiency and higher rates of awakening related to HFs, despite some women not self-reporting the HFs.
- Although the methylation levels of LINE-1 and Alu were higher in those with HFs, these differences weren't statistically significant; however, LINE-1 levels were negatively correlated with age.
A new perspective on isotretinoin in pregnancy: Pregnancy outcomes, evaluation of complex phenotypes, and importance of teratological counselling.
Eur J Obstet Gynecol Reprod Biol
December 2023
Objectives: Teratogens are responsible for 5% of all known causes of congenital anomalies. Isotretinoin, a retinoic acid-derived agent, leads to congenital anomalies in 21-52% of cases when exposure occurs during pregnancy according to studies conducted before 2006. However, rates of congenital anomalies were much lower in later studies.
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- Adherence to long-term medical therapy is crucial for improving outcomes in patients after acute coronary syndrome (ACS), with studies indicating that adherence is often moderate to low, particularly declining within the first year post-discharge.* -
- Research identified 58 studies revealing that nearly 30% of patients stopped one or more medications within 90 days of an ACS event, with factors influencing adherence divided into patient-related, healthcare system-related, and disease-related categories.* -
- Enhanced patient education and early follow-up by healthcare providers can improve medication adherence, which in turn is associated with lower rates of major adverse cardiovascular events.*