Publications by authors named "A Kadhim"
The tumor microenvironment (TME) has drawn much interest recently in the search for innovative cancer therapeutics, especially in light of the growing body of evidence supporting the efficacy of immune checkpoint inhibitors (ICIs). The TME comprises various cell types within the extracellular matrix (ECM), such as immune cells, endothelial cells, and cancer-associated fibroblasts (CAFs). Throughout the malignancy, these cells interact with cancerous cells and with one another.
View Article and Find Full Text PDFVitamin E improves the reproductive system of male rats exposed to busulfan chemotherapy.
Cell Mol Biol (Noisy-le-grand)
January 2025
Vitamin E is a well-known antioxidant and is frequently used as an adjunct treatment in cancer therapy. Busulfan is a commonly used drug for cancer treatment. In this study, twenty-eight male rats, ten weeks old and weighing between 250 and 300 grams, were divided into four groups.
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- Barium fluoride borosilicate glass samples, reinforced with varying amounts of GdO, were created to study their structural, physical, and optical properties as well as their ability to attenuate γ-rays.
- X-ray diffraction confirmed the glasses were amorphous, and did show slight increases in density and molar volume with more GdO.
- UV-Vis spectra indicated increased absorbance and shifts in optical properties, suggesting that these materials could be useful for opto-electronic devices and radiation shielding.
Article Synopsis
- Paclitaxel (PTX) is a key chemotherapy drug effective against multiple cancers, but the development of resistance in patients leads to frequent cancer recurrence.
- Mechanisms of resistance include changes in β-tubulin, drug efflux pathways, and alterations in proteins that control cell death.
- Long non-coding RNAs (lncRNAs) are implicated in these resistance mechanisms and may serve as promising targets for new therapeutic strategies to combat drug resistance in cancer treatment.
Article Synopsis
- The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
- A special data scouting method is utilized to pick out events with low combined momentum in jets.
- This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.