Investigation of the Potential of Nanoparticles as a New Drug Delivery System for Endodontic Treatment.

Background: The application of nanoparticles in endodontic treatment presents a novel approach to drug delivery, potentially enhancing the efficacy of therapeutic agents.

Materials And Methods: In this study, we synthesized and characterized nanoparticles of chitosan, calcium phosphate, and silver using standard protocols. The nanoparticles were then loaded with an antimicrobial agent, chlorhexidine, and incorporated into an endodontic sealer.

ADAMTS4-Specific MR Peptide Probe for the Assessment of Atherosclerotic Plaque Burden in a Mouse Model.

Introduction: Atherosclerosis is the underlying cause of multiple cardiovascular pathologies. The present-day clinical imaging modalities do not offer sufficient information on plaque composition or rupture risk. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is a strongly upregulated proteoglycan-cleaving enzyme that is specific to cardiovascular diseases, inter alia, atherosclerosis.

Prevalence and Characteristics of Dyslipidemia in a Hospital in Madagascar.

Introduction Dyslipidemia is a major risk factor for atherosclerosis and is included in the metabolic syndrome. Data on dyslipidemia are still lacking in some parts of Africa. Our objectives were to report the prevalence of dyslipidemia and to describe the lipid profile of patients in a hospital in Madagascar.

Advancing toxicovigilance of recreational drugs, including new psychoactive substances, by using data from four European poison centres.

Introduction: Common recreational drugs and new psychoactive substances pose challenges to public health. This study investigated the feasibility of merging cases of recreational drug poisoning reported to European poison centres.

Methods: Four European poison centres (Freiburg, Germany; the Netherlands; Sweden and Switzerland) collaborated in a retrospective, observational study.

Sole and co-exposure toxicity of commercial formulations ethoprophos and bispyribac-sodium to Oreochromis niloticus: Assessment of oxidative stress, genotoxicity, and gill ultrastructure.

Aquatic organisms are simultaneously exposed to multiple hazardous chemicals that can be released into water bodies. The current study aimed to evaluate the effect of sublethal concentration (1/50 96 h-LC) of two formulated pesticides: ethoprophos, bispyribac-sodium, and their combination for 1, 2, 3, and 4 weeks on oxidative stress, genotoxic response, and gill morphology in Nile tilapia. This study is the first to demonstrate the toxic effects of ethoprophos and bispyribac-sodium mixture on the commercial important species, Oreochromis niloticus.