Publications by authors named "A K Verheyen"
Background And Aims: Circulating proteins reflecting subclinical vascular disease may improve prediction of atherosclerotic cardiovascular disease (ASCVD). We applied feature selection and unsupervised clustering on proteomic data to identify proteins associated with carotid arteriopathy and construct a protein-based classifier for ASCVD event prediction.
Methods: 491 community-dwelling participants (mean age, 58 ± 11 years; 51 % women) underwent carotid ultrasonography and proteomic profiling (CVD II panel, Olink Proteomics).
The neglected tropical disease onchocerciasis, or river blindness, is caused by infection with the filarial nematode Onchocerca volvulus. Current estimates indicate that 17 million people are infected worldwide, the majority of them living in Africa. Today there are no non-invasive tests available that can detect ongoing infection, and that can be used for effective monitoring of elimination programs.
View Article and Find Full Text PDFDetection of Ascaris lumbricoides infection by ABA-1 coproantigen ELISA.
PLoS Negl Trop Dis
October 2020
Intestinal worms, or soil-transmitted helminths (STHs), affect hundreds of millions of people in all tropical and subtropical regions of the world. The most prevalent STH is Ascaris lumbricoides. Through large-scale deworming programs, World Health Organization aims to reduce morbidity, caused by moderate-to-heavy intensity infections, below 2%.
View Article and Find Full Text PDFArticle Synopsis
- * A new study identified a specific urine biomarker, 2-methyl pentanoyl carnitine (2-MPC), which has high accuracy (85.7% for infections, 90.5% for moderate-to-heavy infections) in identifying A. lumbricoides infections.
- * The levels of 2-MPC in urine decrease significantly after treatment and correlate with the presence of the parasite in stool, suggesting it could be a useful marker for monitoring infection intensity.