Publications by authors named "A K Thotakura"
Article Synopsis
- Immunotherapy shows promise for cancer treatment, but individual immune responses and the lack of reliable biomarkers lead to varied patient outcomes.* -
- Researchers developed a precision ex vivo platform that combines patient-specific tumor and immune cells to explore antitumor responses and predict the effectiveness of treatments.* -
- The study identified a beneficial combination of anti-PD-1 treatment and a specific inhibitor that can overcome resistance, suggesting that tailored immunotherapy can improve personalized cancer care.*
Article Synopsis
- Renal cell carcinoma (RCC) is a prevalent kidney cancer, and PSMA is a protein found in high levels in certain tumors, including metastatic RCC. This study investigates the effectiveness of PSMA-based imaging and treatment in preclinical models of RCC.
- Researchers developed a PSMA-overexpressing murine cell line and used advanced imaging techniques (PET/CT and PET/MR) to assess the accumulation and treatment potential of tailored radiotheranostic agents (Ga-L1, Lu-L1, and Ac-L1) specifically targeting cancerous cells.
- Results showed significantly higher uptake of the PSMA-targeted agents in cancerous cells compared to normal cells, indicating the specificity of these
Unlabelled: S100B is a biochemical marker of head injury and optic nerve sheath diameter (ONSD) is a non-invasive bedside technique to detect intracranial pressure. We aim to demonstrate whether ONSD correlates with S100B protein in head injury patients with contusions and also whether the grade of contusion correlates with S100B protein. This is a prospective study done on head injury patients aged between 18 and 75 years having isolated contusions admitted within 24 h of injury.
View Article and Find Full Text PDFT cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as a bottle neck in the field of cancer immunotherapy have undoubtedly provoked attention. One of the main drivers of T cell exhaustion is prolonged antigen presentation, a prerequisite in the cancer-immunity cycle.
View Article and Find Full Text PDFIntroduction: Ashing is widely used to determine weight fraction of water-free bone that is mineral, but no standard procedure exists and the range of techniques used spans a range of temperatures and times over which the amount of weight loss is variable. We show that variability is largely due to progressive loss of CO from CO ions in the apatite crystal lattice, beginning at 600 ℃, typically used for ashing. We test the effect of varying temperature, time, and weight of sample and develop a reliable method, using small samples.
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