Publications by authors named "A K Thapar"
Individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit varied responses to pharmacological treatments (e.g. stimulants and non-stimulants).
View Article and Find Full Text PDFArticle Synopsis
- The study explores how genetic factors (polygenic scores or PGS) for psychiatric disorders affect the treatment trajectories of individuals with early-onset Major Depressive Disorder (MDD) in secondary care.
- Researchers used data from a large Danish sample, analyzing 10,577 individuals diagnosed with MDD between ages 10-25 to identify different patterns of treatment over seven years.
- Findings reveal specific associations between PGS for ADHD and anorexia with treatment trajectories, suggesting that while genetics may influence the path of depression treatment, the effects are small and not currently useful for predicting clinical outcomes.
Article Synopsis
- The study investigates the effects of maternal vitamin D and omega-3 fatty acid (DHA) deficiencies on neurodevelopmental traits in offspring, using a method called Mendelian randomization to establish causal relationships rather than just correlations.
- Results showed that while higher maternal vitamin-D levels were initially linked to lower ADHD traits in children, this association disappeared when controlling for genetic factors, indicating no causal maternal influence.
- The findings suggest that prior observational studies might have been misleading due to genetic confounding, and that genetic predispositions for autism and ADHD are related to lower levels of vitamin D and DHA in mothers.
Introduction: Previous studies have demonstrated deteriorations in young adult mental health during the COVID-19 pandemic, but evidence suggests heterogeneity in the mental health impacts of the pandemic. We sought to identify factors which may predict changes in psychological distress and wellbeing during the COVID-19 pandemic in UK young adults.
Methods: A total of 2607 young adults from the Millennium Cohort Study were included.
Osteomyelitis complicates 20% of patients with infected diabetic foot ulcers. In this study, 2 strategies for treating pedal osteomyelitis were compared in a pilot study. This was a retrospective, non-randomized, single center 2 arm cohort study, conducted between 2020 and 2022 involving 53 patients at a tertiary limb salvage unit.
View Article and Find Full Text PDF