Intravenous lidocaine for gut function recovery in colonic surgery: a health economic evaluation of the ALLEGRO randomised clinical trial.

Objectives: To compare costs, health outcomes and cost-effectiveness of using intravenous lidocaine (bolus given at induction of anaesthesia, followed by infusion for 6-12 hours) during colorectal surgery to improve the return of gastrointestinal function.

Design: Within-trial planned analysis of data from a randomised controlled trial using an intention-to-treat approach.

Setting: 27 hospitals from across the UK.

Self-monitoring of blood pressure following a stroke or transient ischaemic attack (TASMIN5S): a randomised controlled trial.

Background: Blood pressure (BP) control following stroke is important but currently sub-optimal. This trial aimed to determine whether self-monitoring of hypertension with telemonitoring and a treatment escalation protocol, results in lower BP than usual care in people with previous stroke or transient ischaemic attack (TIA).

Methods: Unblinded randomised controlled trial, comparing a BP telemonitoring-based intervention with control (usual care) for hypertension management in 12 primary care practices in England.

UV LED wastewater disinfection: The future is upon us.

The world's first full-scale, 280 nm UV LED reactor for wastewater disinfection was tested at flows of 545 and 817 m day. The system achieved > 3 average log reduction of total coliform at 545 m day and the 817 m day flow rate achieved over > 2.5 average log reduction for all operational conditions.

Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Randomized Clinical Trial.

Importance: Despite the recovery advantages of minimally invasive surgical techniques, delayed return of gut function after colectomy is a common barrier to timely discharge from hospital.

Objective: To evaluate the effect of 2% perioperative intravenous lidocaine infusion on return of gut function after elective minimally invasive colon resection.

Design, Setting, And Participants: The ALLEGRO trial was a randomized, placebo-controlled, double-blind trial conducted in 27 UK hospitals.

A critical review of ultra-violet light emitting diodes as a one water disinfection technology.

UV light emitting diode (LED) disinfection technologies have advanced over the last decade and expanded the design space for applications in point of use, industrial, and now full-scale water treatment. This literature review examines the progression of UV LED technologies from 2007 to 2023 using key features such as total optical power, price, and wall-plug efficiency. The review found that optical power is increasing while the price per Watt is decreasing; however, the wall plug energy (WPE) is slowly improving over the last decade.