Publications by authors named "A K Spiliotis"
Cilostazol has previously been shown to reduce liver steatosis and enhance hepatic perfusion. We investigated the effects of cilostazol after major hepatectomy in a steatotic rat model. Six weeks prior to surgery, Sprague-Dawley rats were fed with a high-fructose diet.
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- Electrochemotherapy (ECT) uses electroporation alongside chemotherapeutic drugs like bleomycin (BLM) to treat colorectal liver metastases, evaluated in a rat study.
- Three groups of rats received ECT with either intravenous (i.v.), intratumoral (i.t.), or a combination of both methods for BLM injection, and various tumor metrics were measured post-treatment.
- Results indicated that both i.v. and i.v. + i.t. groups had significantly reduced tumor oxygen saturation compared to the i.t. group, but overall tumor necrosis and other tumor characteristics were similar across all treatments, suggesting i.v. administration may be the best option in clinical practice.
Background: The available ablative procedures for the treatment of hepatic cancer have contraindications due to the heat-sink effect and the risk of thermal injuries. Electrochemotherapy (ECT) as a nonthermal approach may be utilized for the treatment of tumors adjacent to high-risk regions. We evaluated the effectiveness of ECT in a rat model.
View Article and Find Full Text PDFBackground: Immunosuppressants represent an effective pharmacological treatment for the remission and management of Crohn's disease (CD); however, it has not been well-defined if these medications are associated with an increased incidence of postoperative complications after intestinal surgery. This retrospective study evaluated the association between immunosuppressive treatment and complications following bowel resection in patients with CD.
Methods: A total of 426 patients with CD who underwent abdominal surgery between 2001 and 2018 were included in the study.