[Collagen from human joint cartilage in deforming arthritis].

Type II collagen of human cartilage has been comparatively studied in norm and at deforming arthrosis. Collagen preparations are characterized by aminoacid composition and electrophoretic mobility in polyacrylamide gel. It is supposed that at deforming arthrosis the degenerative-dystrophic processes in the articular cartilage of man are caused by appearance of procollagen.

[Changes in the structure of postburn keloid scars before and after cryotherapy].

Biochemical and electron microscopy study of the collagen molecule from 14 biopsy specimens of the postburn scar (in 9 patients before and in 5 after cryoeffects) revealed that the postburn scar contains I, II, III and VIII collagen types changed according to the amino acid composition. It was found that after cryogenic effects on the scar there was a tendency to normalization of the collagen structure.

[Structure and properties of collagen in leukemia].

Collagen I was isolated from human bone tissue and from mice bone tissue of the AKR-50 strain at the pronounced stage of leukosis. Dissimilarity of native and leukemic collagens was exhibited after evaluation of their amino acid composition, electrophoretic mobility in polyacrylamide gel containing SDS, content of the carbohydrate moiety as well as of isopoints, elution profiles in reverse-phase chromatography and gel filtration and electron microscopy of SLS-crystallites. Impairments of collagen processing in leukemia appear to be responsible for its alterations in structure and properties.

[Crystalline preparations of acid-soluble collagen from rat skin].

Crystalline preparations of rat skin acid-soluble collagen are a complex of collagen and glycoprotein of noncollagenic nature. Heat denaturation of the preparation, treatment with urea and DS-Na result in decomposition of this complex. Proteins composing it differ in amino acid composition, the presence of -S-S-bonds, the amount of a carbohydrate component, electrophoretic mobility in polyacrylamide gel and solubility in acid medium.