Telomeric RNA quadruplexes as targets for cancer prevention: The therapeutic potential of agonodepsides.

Background: Cancer remains an awful challenge, despite years of targeting proteins to control its relentless growth and spread. Fungal metabolites, a treasure of natural chemicals, offer a glimmer of hope. Telomeres, the cellular "caps," are a focal point in cancer research.

Effects of economic sanctions on cancer care for patients in Iran: a qualitative study.

Background: Due to political and security concerns, Iran has faced stringent sanctions in recent decades, significantly impacting vulnerable cancer patients. According to the latest statistics, the 5-year prevalent cases in Iran were 357,906 for both sexes combined. This study aimed to investigate the perspectives of cancer patients, their families, and non-governmental organizations (NGOs) regarding the ramifications of economic sanctions on cancer diagnosis and treatment.

In silico screening and molecular dynamics analysis of natural DHPS enzyme inhibitors targeting Acinetobacter baumannii.

Over time, antimicrobial agents are losing their credibility in curbing infections due to the development of resistant pathogen strains. The resistant strains have proven to invade living beings and cause various diseases, leading to deaths at an alarming rate. Acinetobacter baumannii is one such pathogen, and to target it through enzyme inhibition, Dihydropteroate synthase enzyme's active site is virtually screened for antimicrobial agents against in-house libraries of natural molecules from medicinally important plants and Agaricus spp.

First professional year student Pharmacists' approaches to resolving drug diversion incidents in a community pharmacy simulation.

Introduction: Drug diversion, the illegal movement or misuse of controlled substances, is a significant public health concern. Pharmacists are crucial in preventing and managing drug diversion but may lack adequate training and confidence in addressing these incidents. This study aimed to evaluate first-year pharmacy students' approaches to resolving drug diversion scenarios using Kings' six models of criminal justice: Medical, Bureaucratic, Status Passage, Power, Due Process, and Crime Control models.

Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions.

Congestion in patients with heart failure (HF) predicts adverse outcomes and is a leading cause of hospitalisation. Understanding congestion mechanisms helps in HF management and underscores the importance of tailored therapies to treat vascular and tissue congestion, improving patient outcomes. In this setting, several tools are available to detect congestion.