Publications by authors named "A K Seck"
Background: In Africa, the scale-up of malaria-control interventions has reduced malaria burden, but progress towards elimination has stalled. Mass drug administration (MDA) is promising as a transmission-reducing strategy, but evidence from low-to-moderate transmission settings is needed. We aimed to assess the safety, coverage, and effect of three cycles of MDA with dihydroartemisinin-piperaquine plus single, low-dose primaquine on Plasmodium falciparum incidence and prevalence in southeast Senegal.
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- Acinetobacter baumannii, especially the carbapenem-resistant strains (CRAB), is a critical pathogen linked to antimicrobial resistance (AMR) and is prioritized by the WHO.
- Phage therapy is being explored as a potential treatment for CRAB infections due to increasing resistance to conventional antibiotics.
- A newly isolated lytic phage, vAbaIN10, exhibits effective lytic activity against CRAB in various conditions and shows promise in advancing treatment options for multidrug-resistant infections.
Background and objectives Antimicrobial resistance (AMR) is a growing global threat, with carbapenemase-producing Enterobacterales (CPEs) representing a critical public health challenge. Rapid and accurate detection of CPEs is essential for controlling fatal bacterial AMR infections. This study evaluated the performance of MacConkey media supplemented with ertapenem (MacErt1 and MacErt2) for the detection of CPEs.
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- * In this study, two bacteriophages, vAbBal23 and vAbAbd25, were isolated from wastewater in Dakar, Senegal, and extensively characterized for their effectiveness against extremely drug-resistant strains of A. baumannii.
- * Both phages showed strong antibacterial properties across various pH levels and temperatures, with the ability to attack both active and biofilm forms of the bacteria, indicating their potential as safe therapeutic agents devoid of harmful genes.
Article Synopsis
- In Senegal, a study evaluated the effectiveness of mass drug administration (MDA) as a strategy to reduce malaria incidence, comparing it to the standard seasonal malaria chemoprevention (SMC) methods.
- The trial was conducted in 60 villages, with one group receiving MDA treatment and the other receiving SMC, both delivered door-to-door.
- Results showed MDA significantly reduced malaria cases by 55% during the peak transmission season, indicating it may be a more effective intervention than standard care without serious side effects reported.