Publications by authors named "A K Sahni"
Article Synopsis
- Therapeutic plasma exchange (TPE) can lead to low calcium levels due to the use of Anticoagulant Citrate Dextrose Solution A, and adding different concentrations of calcium gluconate to human serum albumin may help prevent this issue.* -
- A study comparing two groups of TPE procedures found that while intraprocedural calcium levels were similar, post-procedural ionized calcium was significantly lower in the group with less calcium, leading to more cases of symptomatic hypocalcemia and vasovagal reactions.* -
- The results suggest that using a higher concentration of calcium gluconate (18.6 mg of elemental calcium/100 ml) is safer and more effective in maintaining calcium levels during
Article Synopsis
- The Fontan operation is a procedure for patients with a single ventricle heart condition, historically improved to enhance patient outcomes and minimize complications, but concerns exist regarding the proper sizing of extracardiac conduits.
- A study aimed to evaluate the effects of upsizing these conduits using advanced imaging and fluid dynamics to find optimal sizes for improving blood flow and reducing complications.
- Results showed that upsizing conduits led to significant reductions in power loss (16%-63%), pressure gradients (15%-35%), and variations in local flow dynamics, emphasizing the necessity of personalized treatment strategies for better hemodynamic outcomes.
Left Ventricular Assist Devices (LVADs) are a key treatment option for patients with advanced heart failure, but they carry a significant risk of thromboembolic complications. While improved LVAD design, and systemic anticoagulation regimen, have helped mitigate thromboembolic risks, ischemic stroke due to adverse thromboembolic events remains a major concern with current LVAD therapies. Improved understanding of embolic events, and embolus movement to the brain, is critical to develop techniques to minimize risks of occlusive embolic events such as a stroke after LVAD implantation.
View Article and Find Full Text PDFCell-penetrating peptides (CPPs) enter the cell by two different mechanisms-endocytosis followed by endosomal escape and direct translocation at the plasma membrane. The mechanism of direct translocation remains unresolved. In this work, the direct translocation of nonaarginine (R9) and two cyclic CPPs (CPP12 and CPP17) into Jurkat cells was monitored by time-lapse confocal microscopy.
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