Publications by authors named "A K Saenger"
J Am Coll Cardiol
July 2023
Article Synopsis
- * Different guidelines suggest varying thresholds for hs-cTn concentrations, with some recommending lower levels to identify more low-risk patients.
- * It is essential that patients are at least 2 hours post-symptom onset before evaluation, and extra caution should be taken for older adults, women, and individuals with pre-existing heart conditions.
Clin Chem Lab Med
July 2023
Article Synopsis
- The International Federation of Clinical Chemistry (IFCC C-CB) creates educational resources to help clinical laboratories properly use and understand cardiac biomarkers, focusing on their analytical and clinical relevance.
- Measurements of cardiac troponin (cTn) are crucial in evaluating patients for acute coronary syndrome, making it vital for labs to identify and address analytical problems.
- Two major issues causing falsely elevated cTn levels are macrotroponin, resulting from long-lived cTn-antibody complexes, and heterophilic antibodies, which can distort assay results; the document outlines how to detect and interpret these interferences.
Article Synopsis
- This study compared the effectiveness of a whole blood (WB) point of care (POC) hs-cTnI test with a plasma central laboratory hs-cTnI test in emergency department patients experiencing ischemic symptoms.
- A total of 2152 paired samples from 1089 patients were analyzed, showing that both tests had high concordance rates (91-92%) in detecting troponin levels despite some variance in concentration measurements.
- The results indicated that up to 95% of samples were above the limit of detection for both testing methods, and overall, there was a strong correlation between the two assays, despite variances of up to 53% in cTnI
