A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance.

Amylin analogs, including potential anti-obesity therapies like cagrilintide, act on neurons in the brainstem dorsal vagal complex (DVC) that express calcitonin receptors (CALCR). These receptors, often combined with receptor activity-modifying proteins (RAMPs), mediate the suppression of food intake and body weight. To understand the molecular and neural mechanisms of cagrilintide action, we used single-nucleus RNA sequencing to define 89 cell populations across the rat, mouse, and non-human primate caudal brainstem.

Direct Printing of an Electrochemical Device and Its Interface with Paper for Uric Acid Detection in Human Sweat.

Using a laser-scribed (direct printing) technique, we have fabricated an enzymeless, mediatorless, and paper-interfaced electrochemical device (P-LSG) for uric acid detection on a flexible polyimide sheet. Various paper substrates were investigated, and it was found that Whatman filter paper-1 is promising to obtain the best electrochemical signals at the small volume of electrolyte, i.e.

Approach to DIEP Flap Pedicle Dissection via a Midline Fascial Incision.

In this article, our technique for deep inferior epigastric pedicle dissection utilizing a midline fascial incision is described. Approaching these vessels via a midline facial incision provides facile access to the retrorectus space bilaterally, utilizes a dissection plane that facilitates preservation of nerve and muscle fibers, and allows for both efficient and ergonomic pedicle dissection. This method is safe and easily reproducible and may reduce abdominal donor site morbidity in deep inferior epigastric perforator flap breast reconstruction.

ACT I early feasibility study of the Voyager Ark vascular access device.

Objective: We report the 6-month outcomes of the Ark Cannulation Trial (ACT) I early feasibility study. This investigation examined the Ark as a potential innovative access tool for overcoming cannulation-related challenges and improving arteriovenous fistula (AVF) dependent hemodialysis through targeted cannulation.

Methods: During this first-in-human, interventional, prospective, single arm, single site investigation, 13 patients were treated.

Do children <3years at index surgery for DDH have a better outcome at mid-term follow-up in comparison to children >3years at index surgery? A prospective comparative study.

Background: Diagnosis and management of developmental dysplasia of hip (DDH) in underdeveloped regions is frequently delayed, potentially impacting final outcomes. This prospective study was conducted with the aim of answering the question, "Do children <3 years at index surgery for DDH have better outcome at 5-year follow-up in comparison to children >3 years at index surgery?"

Methods: Between 2016 and 2021, all walking-age children with DDH were prospectively enrolled in the study. The study cohort was divided into 2groups: Group 1 ⩽3 years of age, and Group 2 included children >3 years old.