Publications by authors named "A K Roscoe"
A hydrolyzed N-propionylthiosuccinimide linker is cleaved by metastable fragmentation, increasing reliability of conjugation site identification in conjugate vaccines.
Rapid Commun Mass Spectrom
September 2024
Article Synopsis
- Conjugate vaccines have special places (conjugation sites) that help them work better, and finding these sites is very important for their quality.
- Scientists used advanced techniques like mass spectrometry (MS) to study certain peptides and confirm how they break apart to reveal these conjugation sites.
- The study showed that a specific linker in these peptides can be easily broken down, allowing better identification of conjugation sites, which could lead to stronger vaccines in the future.
Beyond the self: a novel framework to enhance non-technical team skills for anesthesiologists.
Minerva Anestesiol
December 2023
Human factors and non-technical skills (NTS) have been identified as essential contributors to both the propagation and prevention of medical errors in the operating room. Despite extensive study and interventions to nurture and enhance NTS in anesthesiologists, gaps to effective team practice and patient safety remain. Furthermore, the link between added NTS training and clinically significant improved outcomes has not yet been demonstrated.
View Article and Find Full Text PDFArticle Synopsis
- The right ventricle (RV) plays a crucial role in critical illness, but its functions and pathologies are less understood compared to the left ventricle, leading to a greater need for study.
- With the rise of point-of-care echocardiography in critical care, there's a growing ability to detect and monitor RV issues in patients earlier than before.
- The article discusses different states of RV injury, highlighting a lack of a universal definition and emphasizing the importance of understanding RV-pulmonary circulation dynamics to improve diagnosis and treatment.
We performed a systematic review on the agreement and reproducibility of 3 advanced imaging methods, 3-dimensional echocardiography (3DE), cardiac computed tomography (CCT), and cardiac magnetic resonance (CMR), for quantifying aortic regurgitation (AR) severity. Medline, Embase, and Cochrane databases were systematically searched using the PICO model from inception to February 4, 2022, for publications that quantified AR severity with 3DE, CCT, or CMR. Measurement agreement and intraobserver and interobserver reproducibility results were extracted from each study.
View Article and Find Full Text PDF