Skin, as the primary interface with the external environment, is susceptible to damage, posing a formidable challenge for complete restoration in adult skin injuries. Wound healing remains a clinical challenge, necessitating advanced biomaterials to support cell proliferation, modulate inflammation, and combat infections. Among several options, hydrogel can be a capable contender for biological dressings.
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) is known for its aggressive nature, typically presenting as high-grade tumors that grow and spread quickly in all breast cancer types. Several studies have reported a strong correlation between cancer and microbial infections due to a compromised immune system. The most frequent infection associated with surface malignancies, including breast cancer, is Candidiasis, which is majorly caused by .
View Article and Find Full Text PDFThe upcoming era of flexible and wearable electronics necessitates the development of low-cost, flexible, biocompatible substrates amenable to the fabrication of active devices such as electronic devices, sensors and transducers. While natural biopolymers such as Silk are robust and biocompatible, long-term flexibility is a concern due to the inherent brittle nature of soft Silk thin films. This work elucidates the preparation and characterization of Silk-polyurethane (Silk-PU) composite film that provides long-duration flexibility.
View Article and Find Full Text PDFThe development of active therapeutic agents to treat highly metastatic cancer while minimizing damage to healthy cells is of utmost importance. Due to potential antioxidant properties, hydroxycinnamic acid derivatives (caffeic acid and -coumaric acids) were found to inhibit highly metastatic breast cancer cell growth both and without much effect on normal cells. Especially due to the structure-activity relationships, ester and amide derivatives of hydroxycinnamic acids are reported to gain much higher radical scavenging ability than their naked hydroxycinnamic acid analogs like caffeic acid and -coumaric acid.
View Article and Find Full Text PDFOpportunistic pathogenic microbial infections pose a significant danger to human health, which forces people to use riskier, more expensive, and less effective drugs compared to traditional treatments. These may be attributed to several factors, such as overusing antibiotics in medicine and lack of sanitization in hospital settings. In this context, researchers are looking for new options to combat this worrying condition and find a solution.
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