Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection.

Donor-derived fecal microbiota treatments are efficacious in preventing recurrent Clostridioides difficile infection (rCDI), but they have inherently variable quality attributes, are difficult to scale and harbor the risk of pathogen transfer. In contrast, VE303 is a defined consortium of eight purified, clonal bacterial strains developed for prevention of rCDI. In the phase 2 CONSORTIUM study, high-dose VE303 was well tolerated and reduced the odds of rCDI by more than 80% compared to placebo.

Does social support buffer the impact of stress on health among people living with sickle cell disease? A cross-sectional study.

In this cross-sectional study, we examined the contributions of social support in mitigating the burden that sickle cell disease (SCD) has on the well-being of patients living with the condition. SCD patients ( = 139) in Nigeria completed measures of sickle cell distress, social support, and quality of life. Although we found that SCD distress was strongly associated with poorer quality of life, across domains; social support did not mitigate the impact that SCD distress had on the quality of life of patients.

Hospital staff's experiences of unsafe staffing levels and employers' responses to their concerns: a survey.

There is a wealth of evidence that demonstrates a link between inadequate nurse staffing levels and suboptimal patient care. Over the last decade, policies and legislation on safe nurse staffing levels have been developed for specific settings and countries in the UK, all of which emphasise employers' responsibility in responding to staff's concerns about unsafe staffing. However, the effectiveness of mechanisms for monitoring and responding to such concerns is unclear.

Parotidectomy Trends Toward Outpatient for Benign Disease.

Objective: We evaluate the safety of outpatient parotidectomy. We evaluate factors that lead to planned admission and compare costs. We evaluate trends toward outpatient, and the outcomes of switching admission status, total versus superficial approach, and ambulatory versus hospital site.