Publications by authors named "A K Patwari"
Article Synopsis
- - The study analyzed the effects of cytogenetic abnormalities in 283 AL amyloidosis patients treated with daratumumab-based therapies, focusing on abnormalities like t(11;14), deletion(13q), and gain/amp(1q).
- - Among various subgroups, only +1q showed a significant lower rate of very good partial response and was linked to worse hematologic event-free survival, while t(11;14) did not negatively impact overall survival.
- - The findings suggest that patients with the +1q abnormality may benefit from targeted clinical trials with novel immunotherapies to improve their treatment outcomes.
Article Synopsis
- The Glasgow prognostic score (GPS) and CAR-HEMATOTOX (CAR-HT) score help identify multiple myeloma (MM) patients at risk for immune-related side effects and early death during cellular immunotherapy.
- A study involving 126 MM patients treated with T-cell redirecting bispecific antibodies (bsAb) assessed the impact of these scores on patient outcomes.
- While 19% of patients were deemed high risk according to GPS, they did not experience worse outcomes, but those classified as high risk by CAR-HT faced more infections and had lower survival rates, indicating the need for better infection management.
Background: Polyelectrolyte grafted 'soft' nanochannels are known to enhance electrokinetic energy conversion efficiency, paving the way for a sustainable energy harvesting mechanism. However, the true potential of their efficacy remains to be tapped, as attributed to a deficit in accounting for the interplay between solution pH and ion partitioning effect arising due to permittivity contrast between the coated layer and the bulk media, leading to predictions of an erroneous ionic distribution and a wrongly estimated electrokinetic response.
Results: We unravel the electrokinetic behavior of a pH-regulated zwitterionic polyelectrolyte layer grafted nanofluidic system.
Spinal dural arteriovenous fistula (AVF) is an abnormal shunting between the segmental artery and radicular vein adjacent to the dural root sleeve in the spine. This is the most common vascular malformation of the spinal cord and is a rare but treatable cause of para or quadriplegia. It most commonly occurs in elderly men and often affects the thoracolumbar region.
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