Publications by authors named "A K Niskanen"

Large and highly repetitive genomes are common. However, research interests usually lie within the non-repetitive parts of the genome, as they are more likely functional, and can be used to answer questions related to adaptation, selection and evolutionary history. Exome capture is a cost-effective method for providing sequencing data from protein-coding parts of the genes.

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  • Maternal immune activation (MIA) during pregnancy may contribute to psychiatric disorders in children, but its effects on brain development and sex differences are not fully understood.
  • A study analyzed data from 2,635 mother-child pairs to explore how maternal levels of CRP, a marker of inflammation, correlate with offspring brain structure, focusing on cortical thickness, surface area, and volume.
  • Findings reveal that normal maternal CRP levels show different effects on brain development in boys and girls, while higher CRP levels are linked to changes in brain structure in both sexes, highlighting the importance of sex and inflammation in neurodevelopment.
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Meiotic recombination through chromosomal crossing-over is a fundamental feature of sex and an important driver of genomic diversity. It ensures proper disjunction, allows increased selection responses, and prevents mutation accumulation; however, it is also mutagenic and can break up favorable haplotypes. This cost-benefit dynamic is likely to vary depending on mechanistic and evolutionary contexts, and indeed, recombination rates show huge variation in nature.

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Dispersal affects evolutionary processes by changing population size and genetic composition, influencing the viability and persistence of populations. Investigating which mechanisms underlie variation in dispersal phenotypes and whether populations harbour adaptive potential for dispersal is crucial to understanding the eco-evolutionary dynamics of this important trait. Here, we investigate the genetic architecture of dispersal among successfully recruited individuals in an insular metapopulation of house sparrows.

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  • Pinus sylvestris, or Scots pine, is an important conifer found in the boreal forests of Eurasia, but its complex genome complicates genetic research.
  • Researchers developed a 50K SNP genotyping array called 'PiSy50k' after screening 480 samples to identify 47,712 high-quality SNPs for study and breeding purposes.
  • The PiSy50k array demonstrated high accuracy and effectiveness in distinguishing populations from Finland and Scotland, making it a useful resource for future genetic studies in Scots pine.
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