Publications by authors named "A K Mwatha"
Article Synopsis
- The study aimed to establish the recommended phase II dose (RP2D) and assess the safety and initial effectiveness of the drug unesbulin combined with dacarbazine (DTIC) in patients with advanced leiomyosarcoma (LMS).
- Patients with advanced LMS received escalating doses of unesbulin twice weekly along with DTIC, with the RP2D determined by monitoring dose-limiting toxicities (DLTs) during the treatment cycles.
- The RP2D was found to be 300 mg of unesbulin, resulting in a 24.1% objective response rate among those evaluated, indicating a promising safety and efficacy profile for this treatment in severely pretreated adults.
Background: Respiratory distress syndrome (RDS) is the most common respiratory disease in premature babies and the major cause of morbidity and mortality among preterm babies. Effective treatment of these babies requires exogenous surfactant and/or mechanical ventilation but these are of limited availability in low and middle income countries. A cheaper, simpler and more accessible treatment for preterms with RDS called bubble-continuous positive airway pressure (bCPAP) has been reported to be effective in treating RDS in preterm babies with varying levels of effectiveness ranging from 42% to 85%.
View Article and Find Full Text PDFExtended Prophylaxis With Nevirapine Does Not Affect Growth in HIV-Exposed Infants.
J Acquir Immune Defic Syndr
December 2019
Background: Effects of prolonged nevirapine prophylaxis exposure on growth among HIV-exposed uninfected (HEU) infants are unknown. This study examines the impact of extended nevirapine prophylaxis from 6 weeks to 6 months on the growth of HEU infants followed for 18 months and also identifies correlates of incident wasting, stunting, underweight, and low head circumference in the HPTN 046 trial.
Methods: Intention-to-treat analysis examined the effect of extended nevirapine exposure on: weight-for-age Z-score, length-for-age Z-score, weight-for-length Z-score, and head circumference-for-age Z-score.
Objectives: The objective of this study was to compare the effects of three tongue hygiene regimens on oral malodor.
Methods: This was a single-center, randomized, parallel design study with three treatment groups. Subjects were randomly assigned to perform tongue hygiene with either the Philips Sonicare TongueCare+ BreathRx regimen (STC), Listerine Cool Mint antiseptic rinse (LCM), or tongue brushing with an ADA reference manual toothbrush (MTB).
Objectives: To compare the effect of a powered and a manual toothbrush on gingivitis and plaque following two and four weeks of home use.
Methods: This was a randomized, parallel-design, single-blind clinical trial. Eligible participants were generally healthy non-smoking manual toothbrush users aged 18-65 years, with a plaque score of = 1.