Comparison of Efficacy of the Combination of Topical Tazarotene Gel and Oral Fluconazole Versus Oral Fluconazole Monotherapy in the Treatment of Onychomycosis.

Background: Onychomycosis is a chronic fungal infection of the nails of toes and fingers, with an ongoing search for appropriate and more officious treatment modalities because the currently applied regimens are far from perfect.

Objective: The objective of this study was to compare the efficacy of the combination of topical tazarotene 0.1% gel and oral fluconazole with weekly oral fluconazole monotherapy in the treatment of OM.

miR-107 suppresses porcine granulosa cell proliferation and estradiol synthesis while promoting apoptosis via targeting PTGS2.

The proliferation, steroid metabolism, and apoptosis of porcine ovarian granulosa cells (GCs) are critical for follicular development. MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene expression post-transcriptionally and modulate signaling networks involved in various cellular processes. In this study, we identify miR-107, a conserved miRNA, as a key regulator of porcine follicle development through its effects on GCs proliferation, steroid metabolism, and apoptosis.

Rhizospheric crosstalk: A mechanistic overview of how plant secondary metabolites alleviate abiotic stresses.

Plants often encounter incompatible growing conditions, such as drought, extreme temperatures, salinity, and heavy metals, which negatively impact their growth and development, resulting in reduced yield and, in severe cases, plant death. These stresses trigger the synthesis of plant secondary metabolites (PSMs), which help plants develop strategies to deter enemies, combat pathogens, outcompete competitors, and overcome environmental restraints. PSMs are released into the rhizosphere and play crucial roles in plant defense and communication.

The forgotten link: how the oral microbiome shapes childhood growth and development.

Childhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive and physical well-being. Emerging evidence highlights the pivotal role of the oral microbiome-a dynamic microbial ecosystem-in influencing nutritional status, immune response, and overall systemic health. This review explores the intricate interplay between the oral microbiome and stunting, emphasizing mechanisms such as microbial dysbiosis, its impact on nutrient absorption, and immune modulation.