Advance directives in amyotrophic lateral sclerosis - a systematic review and meta-analysis.

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motoneuron. It is associated with a life expectancy of 2-4 years after diagnosis. Individuals experience paralysis, dysphagia, respiratory failure and loss of communicative function, rendering advance care planning (ACP) critically important.

Orthodontic Aligners: Current Perspectives for the Modern Orthodontic Office.

Orthodontic aligners are changing the practice of orthodontics. This system of orthodontic appliances is becoming the mainstay appliance of choice for orthodontic offices in many countries. Patient preferences and lifestyle needs have made this appliance the primary choice when seeking care.

To Study Mean Corpuscular Volume in Alcoholic Liver Disease Patients and to Compare with Child-Pugh Score to Predict the Severity.

Introduction: Liver injury caused by the alcohol abuse is called alcoholic liver disease (ALD). In particular, ethanol exposure induces cell membrane remodeling in different cells and lipid vesicles including membrane fluidization. These phenomena may be related to the effects of alcohol on the red blood cells (RBCs) membrane because unmetabolized ethanol can have a direct effect on membrane properties.

evaluation of the compounds of the ayurvedic drug, AYUSH-64, for the action against the SARS-CoV-2 main protease.

Background: Outbreak of Corona Virus Disease in late 2019 (COVID-19) has become a pandemic global Public health emergency. Since there is no approved anti-viral drug or vaccine declared for the disease and investigating existing drugs against the COVID-19.

Objective: AYUSH-64 is an Ayurvedic formulation, developed and patented by Central Council of Research in Ayurvedic Sciences, India, has been in clinical use as anti-malarial, anti-inflammatory, anti-pyretic drug for few decades.

Characterization of ambient PM at a suburban site of Agra: chemical composition, sources, health risk and potential cytotoxicity.

The present study was conducted at a University campus of Agra to determine concentrations of crustal and trace elements in submicron mode (PM) particles to reveal sources and detrimental effects of PM-bound metals (Cr, Cd, Mn, Zn, As, Co, Pb, Cu and Ni) in samples collected in the foggy (1 December 2016-17 January 2017) and non-foggy periods (1 April 2016-30 June 2016). Samples were collected twice a week on preweighed quartz fibre filters (QM-A 47 mm) for 24 h using Envirotech APM 577 (flow rate 10 l min). Mass concentration of PM was 135.