Publications by authors named "A K Mallia"
Lipid droplets (LDs), highly dynamic cellular organelles specialized in lipid storage and maintenance of lipid homeostasis, contain several proteins on their surface, among which the perilipin (Plin) family stands out as the most abundant group of LD-binding proteins. They play a pivotal role in influencing the behavior and functionality of LDs, regulating lipase activity, and preserving a balance between lipid synthesis and degradation, which is crucial in the development of obesity and abnormal accumulation of fat in non-adipose tissues, causing negative adverse biological effects, such as insulin resistance, mitochondrial dysfunction, and inflammation. The expression levels of Plins are often associated with various diseases, such as hepatic steatosis and atherosclerotic plaque formation.
View Article and Find Full Text PDF: Diabetes, particularly type 2 diabetes (T2D), is linked with an increased risk of developing coronary heart disease (CHD). The present study aimed to evaluate potential circulating biomarkers of CHD by adopting a targeted proteomic approach based on proximity extension assays (PEA). : The study was based on 30 patients with both T2D and CHD (group DC), 30 patients with T2D without CHD (group DN) and 29 patients without diabetes but with a diagnosis of CHD (group NC).
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- * The diagnosis was complicated by the patient’s history of breast cancer, but radionuclide imaging indicated uptake of DOTATATE in the lung nodules, supporting the rare diagnosis of DIPNECH.
- * Treatment included oral steroids with no improvement, followed by octreotide, which significantly relieved her symptoms; the case highlights the importance of recognizing DIPNECH among common respiratory conditions for timely diagnosis and management.
Article Synopsis
- Valvular disease affects many people worldwide and is linked to pulmonary venous hypertension, which disrupts gas exchange.
- A study involving 44 patients (36 needing aortic valve replacement, 8 requiring a second surgery) and 10 healthy controls found that those with recurrent surgery had higher levels of immature surfactant protein B (proSP-B).
- The findings suggest that proSP-B could be a useful marker for assessing damage to the alveolar-capillary membrane in patients with valvular heart disease.
Article Synopsis
- Atherosclerosis involves lipid buildup and plaque formation in arteries, significantly driven by oxidative modifications of low-density lipoprotein (ox-LDL).
- Ox-LDL contributes to inflammation, foam-cell formation, and smooth muscle cell issues, with LOX-1 being a key receptor that exacerbates these effects and promotes plaque development.
- The relationship between LOX-1 activation and atherosclerosis is complex, and more research is needed to see if targeting LOX-1 could help in preventing or treating atherosclerosis.